https://oxidativehealth.info/index.php?action=history&feed=atom&title=4-hydroxy-2-nonenal_%284-HNE%29 2026-05-08T15:47:26Z Revision history for this page on the wiki MediaWiki 1.39.2 https://oxidativehealth.info/index.php?title=4-hydroxy-2-nonenal_(4-HNE)&diff=36&oldid=prev 2023-03-18T15:44:58Z

<p>Created page with &quot;== Description == &#039;&#039;&#039;4-Hydroxynonenal&#039;&#039;&#039;, or &#039;&#039;&#039;4-hydroxy-2-nonenal&#039;&#039;&#039; or &#039;&#039;&#039;4-HNE&#039;&#039;&#039; or &#039;&#039;&#039;HNE&#039;&#039;&#039;, (&#039;&#039;&#039;C9H16O2&#039;&#039;&#039;), is an α,β-unsaturated hydroxyalkenal that is produced by <a href="/index.php?title=Lipid_peroxidation&amp;action=edit&amp;redlink=1" class="new" title="Lipid peroxidation (page does not exist)">lipid peroxidation</a> in cells. 4-HNE is the primary α,β-unsaturated hydroxyalkenal formed in this process. It is a colorless oil. It is found throughout animal tissues, and in higher quantities during <a href="/index.php?title=Oxidative_stress" title="Oxidative stress">oxidative stress</a> due to the increase in the lipid peroxidation chain reaction, due to the...&quot;</p> <p><b>New page</b></p><div>== Description ==<br /> &#039;&#039;&#039;4-Hydroxynonenal&#039;&#039;&#039;, or &#039;&#039;&#039;4-hydroxy-2-nonenal&#039;&#039;&#039; or &#039;&#039;&#039;4-HNE&#039;&#039;&#039; or &#039;&#039;&#039;HNE&#039;&#039;&#039;, (&#039;&#039;&#039;C9H16O2&#039;&#039;&#039;), is an α,β-unsaturated hydroxyalkenal that is produced by [[lipid peroxidation]] in cells. 4-HNE is the primary α,β-unsaturated hydroxyalkenal formed in this process. It is a colorless oil. It is found throughout animal tissues, and in higher quantities during [[oxidative stress]] due to the increase in the lipid peroxidation chain reaction, due to the increase in stress events. 4-HNE has been hypothesized to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.<br /> <br /> Since 1991, [[aldehydes]] like 4-HNE are receiving a great deal of attention because they are being considered as possible causal agents of numerous diseases, such as chronic inflammation, neurodegenerative diseases, adult respiratory distress syndrome, atherogenesis, diabetes and different types of cancer.&lt;ref&gt;https://en.wikipedia.org/wiki/4-Hydroxynonenal&lt;/ref&gt;<br /> <br /> == Relevant Studies ==<br /> [[Formation of 4-hydroxynonenal from cardiolipin oxidation: intramolecular peroxyl radical addition and decomposition (2011)]]<br /> [[Category:4-hydroxy-2-nonenal (4-HNE)]]<br /> [[Category:Lipid peroxidation]]</div>

Oxidative Health