Melatonin in Mitochondria: Mitigating Clear and Present Dangers (2020): Difference between revisions
No edit summary |
No edit summary |
||
| Line 19: | Line 19: | ||
Reiter RJ, Ma Q, Sharma R. Melatonin in Mitochondria: Mitigating Clear and Present Dangers. Physiology (Bethesda). 2020 Mar 1;35(2):86-95. doi: 10.1152/physiol.00034.2019. PMID: 32024428. | Reiter RJ, Ma Q, Sharma R. Melatonin in Mitochondria: Mitigating Clear and Present Dangers. Physiology (Bethesda). 2020 Mar 1;35(2):86-95. doi: 10.1152/physiol.00034.2019. PMID: 32024428. | ||
[[Category:Research Papers]] | [[Category:Research Papers]] | ||
[[Category:Reviews]] | |||
[[Category:Mitochondria]] | [[Category:Mitochondria]] | ||
Revision as of 15:15, 23 March 2023
Explanation
TBA
Highlights
TBA
Related Studies
TBA
Official Abstract
In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.
Publication Details
Authors
Russel J. Reiter, Qiang Ma, and Ramaswamy Sharma
Journal
PubMed
https://pubmed.ncbi.nlm.nih.gov/32024428/
Full Text
https://journals.physiology.org/doi/full/10.1152/physiol.00034.2019
Citation
Reiter RJ, Ma Q, Sharma R. Melatonin in Mitochondria: Mitigating Clear and Present Dangers. Physiology (Bethesda). 2020 Mar 1;35(2):86-95. doi: 10.1152/physiol.00034.2019. PMID: 32024428.