Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome (2013): Difference between revisions

From Oxidative Health
Jump to navigation Jump to search
No edit summary
No edit summary
 
Line 1: Line 1:
==Abstract==
<blockquote>Lipid peroxidation products such as 4-hydroxynonenal (HNE) are known to be increased in response to oxidative stress, and are known to cause dysfunction and pathology in a variety of tissues during periods of oxidative stress. The aim of the current study was to determine the chronic (repeated HNE exposure) and acute effects of physiological concentrations of HNE towards multiple aspects of adipocyte biology using differentiated 3T3-L1 adipocytes. Our studies demonstrate that acute and repeated exposure of adipocytes with physiological low concentrations of HNE is sufficient to promote subsequent oxidative stress, impaired adipogenesis, alter the expression of adipokines, and increase lipolytic gene expression and increase FFA release. These results provide an insight in to the role of HNE induced oxidative stress in regulation of adipocyte differentiation and adipose dysfunction. Taken together, these data indicate a potential role for HNE promoting diverse effects towards adipocyte homeostasis and adipocyte differentiation, which may be important to the pathogenesis observed in obesity and metabolic syndrome.</blockquote>
==Explanation==
==Explanation==
TBA  
TBA  
Line 5: Line 7:
==Related Studies==
==Related Studies==
TBA
TBA
==Official Abstract==
<blockquote>Lipid peroxidation products such as 4-hydroxynonenal (HNE) are known to be increased in response to oxidative stress, and are known to cause dysfunction and pathology in a variety of tissues during periods of oxidative stress. The aim of the current study was to determine the chronic (repeated HNE exposure) and acute effects of physiological concentrations of HNE towards multiple aspects of adipocyte biology using differentiated 3T3-L1 adipocytes. Our studies demonstrate that acute and repeated exposure of adipocytes with physiological low concentrations of HNE is sufficient to promote subsequent oxidative stress, impaired adipogenesis, alter the expression of adipokines, and increase lipolytic gene expression and increase FFA release. These results provide an insight in to the role of HNE induced oxidative stress in regulation of adipocyte differentiation and adipose dysfunction. Taken together, these data indicate a potential role for HNE promoting diverse effects towards adipocyte homeostasis and adipocyte differentiation, which may be important to the pathogenesis observed in obesity and metabolic syndrome.</blockquote>
==Publication Details==
==Publication Details==
===Authors===
===Authors===

Latest revision as of 04:17, 24 March 2023

Abstract

Lipid peroxidation products such as 4-hydroxynonenal (HNE) are known to be increased in response to oxidative stress, and are known to cause dysfunction and pathology in a variety of tissues during periods of oxidative stress. The aim of the current study was to determine the chronic (repeated HNE exposure) and acute effects of physiological concentrations of HNE towards multiple aspects of adipocyte biology using differentiated 3T3-L1 adipocytes. Our studies demonstrate that acute and repeated exposure of adipocytes with physiological low concentrations of HNE is sufficient to promote subsequent oxidative stress, impaired adipogenesis, alter the expression of adipokines, and increase lipolytic gene expression and increase FFA release. These results provide an insight in to the role of HNE induced oxidative stress in regulation of adipocyte differentiation and adipose dysfunction. Taken together, these data indicate a potential role for HNE promoting diverse effects towards adipocyte homeostasis and adipocyte differentiation, which may be important to the pathogenesis observed in obesity and metabolic syndrome.

Explanation

TBA

Highlights

TBA

Related Studies

TBA

Publication Details

Authors

Kalavathi Dasuri, Philip Ebenezer, Sun Ok Fernandez-Kim, Le Zhang, Zhanguo Gao, Annadora J Bruce-Keller, Linnea R Freeman, and Jeffrey N. Keller

Journal

Free Radical Research

PubMed

https://pubmed.ncbi.nlm.nih.gov/23025469/

Full Text

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/

Citation

Dasuri K, Ebenezer P, Fernandez-Kim SO, Zhang L, Gao Z, Bruce-Keller AJ, Freeman LR, Keller JN. Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome. Free Radic Res. 2013 Jan;47(1):8-19. doi: 10.3109/10715762.2012.733003. Epub 2012 Oct 16. PMID: 23025469; PMCID: PMC4038367.

Retrieved from "https://oxidativehealth.info/index.php?title=Role_of_Physiological_Levels_of_4-Hydroxynonenal_on_Adipocyte_Biology:_Implications_for_Obesity_and_Metabolic_Syndrome_(2013)&oldid=251"