DNA damage induced by endogenous aldehydes: current state of knowledge (2011)
Abstract
DNA damage plays a major role in various pathophysiological conditions including carcinogenesis, aging, inflammation, diabetes and neurodegenerative diseases. Oxidative stress and cell processes such as lipid peroxidation and glycation induce the formation of highly reactive endogenous aldehydes that react directly with DNA, from aldehyde-derived DNA adducts and lead to DNA damage. In occasion of persistent conditions that influence the formation and accumulation of aldehyde-derived DNA adducts the resulting unrepaired DNA damage causes deregulation of cell homeostasis and thus significantly con- tributes to disease phenotype. Some of the most highly reactive aldehydes produced endogenously are 4-hydroxy-2-nonenal, malondialdehyde, acrolein, crotonaldehyde and methylglyoxal. The mutagenic and carcinogenic effects associated with the elevated levels of these reactive aldehydes, especially, under conditions of stress, are attributed to their capability of causing directly modification of DNA bases or yielding promutagenic exocyclic adducts. In this review, we discuss the current knowledge on DNA damage induced by endogenously produced reactive aldehydes in relation to the pathophysiology of human diseases.
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Publication Details
Authors
Georgia-Persephoni Voulgaridou, Ioannis Anestopoulos, Rodrigo Franco, Mihalis I. Panayiotidis, Aglaia Pappa
Journal
PubMed
https://pubmed.ncbi.nlm.nih.gov/21419140/
Full Text
https://linkinghub.elsevier.com/retrieve/pii/S0027-5107(11)00056-X
Citation
Voulgaridou GP, Anestopoulos I, Franco R, Panayiotidis MI, Pappa A. DNA damage induced by endogenous aldehydes: current state of knowledge. Mutat Res. 2011 Jun 3;711(1-2):13-27. doi: 10.1016/j.mrfmmm.2011.03.006. Epub 2011 Mar 16. PMID: 21419140.