Melatonin in Mitochondria: Mitigating Clear and Present Dangers (2020)
Official Abstract
In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.
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Publication Details
Authors
Russel J. Reiter, Qiang Ma, and Ramaswamy Sharma
Journal
PubMed
https://pubmed.ncbi.nlm.nih.gov/32024428/
Full Text
https://journals.physiology.org/doi/full/10.1152/physiol.00034.2019
Citation
Reiter RJ, Ma Q, Sharma R. Melatonin in Mitochondria: Mitigating Clear and Present Dangers. Physiology (Bethesda). 2020 Mar 1;35(2):86-95. doi: 10.1152/physiol.00034.2019. PMID: 32024428.